ABSTRACT
The objective of current study was to compare the efficacy of three different anaesthesia induction approachesi.e. Inj propofol, Inj etomidate and admixture of Inj propofol and Inj etomidate in maintaining hemodynamicstability during induction and following Proseal LMA insertion in laparoscopic cholecystectomy. Patientswere randomly divided in to 3 groups with 90 patients each and received 2.5mg/kg of propofol(P), 0.3mg/kgof etomidate(E) and 1mg/kg of propofol+0.2mg/kg of etomidate which was mixed in a 20ml syringe. We alsostudied side-effects like PONV, myoclonus, pain on Injection, allergic reactions and thrombophlebitis. Wefound that the use of P-E admixture for induction of Proseal LMA provides hemodynamic stability as itprevents hypotension caused by propofol and also hypertension caused by etomidate when used alone. Admixturewas also associated with less incidence of other side effects like PONV, pain on Injection and myoclonus. Weconcluded that combination of propofol and etomidate for induction of anaesthesia for Proseal LMA issignificantly better than either drug used alone
ABSTRACT
The current study was done to compare the safety profile of Ondansetron, Ramosetron and Palonosetron. 150 female patients undergoing elective Laparoscopic Cholecystectomy were randomly divided into 3 groups with 50 patients each and received 4mg of Ondansetron, 0.3mg of Ramosetron and 0.075mg of Palonosetron respectively for PONV prophylaxis. Patients were observed for QTc interval changes &other side effects like headache, dizziness, drowsiness and myalagia in addition to incidence of post operative nausea & vomiting. The incidence of QTc interval prolongation at various time intervals and side effects like headache, dizziness, drowsiness, myalagia also did not show any statistically significant difference. We concluded that safety profile and side effects of all the three drugs were comparable when used in this manner. As for as QTc interval change is concerned both ondansetron & Ramosetron caused the prolongation of corrected QTc interval but in no patient it was found to be more than 470 ms
ABSTRACT
Abstract The current study was conducted to assess the efficacy of buprenorphine as an adjuvant in IVRA with 0.5 % lidocaine on 50 patients aged between 18-65 years, of either sex, scheduled for hand or forearm surgery, who were divided randomly into two groups of 25 each. Group BL- Patients in the group received 10 ml of the preservative free lidocaine 2% diluted with saline, to a total volume of 40ml. Group BBPatients in the group received 10 ml of the preservative free lidocaine 2% mixed with 1ml of buprenorphine 0.3mg diluted with saline to a total volume of 40ml. Various parameters like onset and duration of sensory and motor blockade, degree of intra and postoperative analgesia, and requirement of the postoperative analgesia and occurrence of any complications was noted. The time of onset for sensory block was shorter in group BB (4.0 + 0.35min) as compared to group BL (6.0 + 0.6 min) (p=0.001). The onset of motor block did not differ between the groups (p=0.05). In all patients in group BL analgesic duration did not last for more than 2/3 hours (0.33 + 0.2 hours). In group BB, mean analgesic duration was 6.7 + 1.2 hours. Consumption of Diclofenac was also markedly lower in group BB (80.0 + 9.0mg vs. 214 + 33mg). Addition of buprenorphine as an adjuvant in 0.5% preservative free lidocaine(40 ml volume) significantly improves the postoperative analgesia and it also improved the onset of sensory block. Consumption of Diclofenac was also markedly lower in group BB (80.0 + 9.0 mg vs. 214 + 33 mg).